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18th International Conference on Metabolomics and Proteomics, will be organized around the theme “”

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\r\n Metabolomics is the study of the metabolome/metabolites, the unique biochemical fingerprint of all cellular processes. It is an Omics technology that allows simultaneous, global, and comprehensive characterization of small molecules in a biological system. It is the large-scale study of small molecules within a mass range of 50 – 1500 Daltons (Da), commonly known as metabolites, within cells, bio fluids, tissues or organisms. These metabolites within biological samples under given genetic, nutritional or environmental conditions are known as metabolome.

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\r\n Systems biology is the study of biological systems at a cellular, molecular and organism level, as an integrated and interacting network of genes, proteins and biochemical reactions which give rise to life. It can be used to systematically at all levels, from molecules to entire systems and its integration into quantitative models to gain knowledge in order to make accurate simulation of biological processes possible. The technologies such as genomics, bioinformatics, proteomics, mathematical and computational models are used for predicting dynamical behaviour and quantitative measurements of the behaviour.

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\r\n Metabolomics along with the system biology can be used to identify endogenous metabolites that will modify the protein expression. The main aim of Omics technologies is to reveal unexpected properties of biological systems by their nature. On behalf of metabolomics, liquid and gas chromatography coupled to mass spectrometry are well satisfactory for coping with high sample numbers in reliable measurement times with respect to both technical accuracy and quantitation of small weight metabolites. This prospective is a prerequisite for the analysis of dynamic systems. So, metabolomics is a key for systems biology.

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\r\n Synthetic biology main purpose is to create novel biological functions and systems by combining biology with engineering stream. The workflow of the development of novel biological functions with synthetic biology is ideally linear which will be attainable with the quantitative engineering approach, high-quality predictive models, and libraries of well-characterized parts. In particular phases of synthetic biology workflow differing types of metabolic models, mathematical representations of metabolism and its components, enzymes and metabolites, are useful.

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\r\n Computational Biology may be a rapidly emerging field, at the interface of physics, arithmetic, computing and biology to review, analyse and understand complex biological systems by taking corresponding integrated systems using computational methodologies. The recent advances in computational methodologies are high throughput techniques and computational power. Computational systems biology provides a point of merging for genomics, proteomics, metabolomics and computational modelling and plays a key role in the fast progression of the evolving field by the outstanding developments in biology and computer science.

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\r\n Plant metabolomics may be a recent research field that has gained increasing interest within the past few years and is applied for sub atomic level of the entire metabolite and metabolome of plants under particular conditions. Metabolomics is applied for a better understanding the relation between genes and the biochemical composition of a plant tissue in response to its environment conditions and this information can be further used to assess gene function. The environmental metabolomics is use of metabolomics strategies to investigate the connections of life forms with their surroundings.

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\r\n Pharmaco-metabolomics used to determine the metabolic biomarkers that could potentially predict different responses of clinical drugs by identifying differential metabolites at baseline and correlating their variations with the therapeutic outcomes. Presently, Pharmaco-metabolomics remains in its infancy because most pharmaco-metabolomics studies are merely focused on revealing the correlation between baseline metabotypes which are influenced by factors like-gut, ages, drug intake and diets microbiota with drug responses or disease susceptibility to review and decrease the metabolic bases.

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\r\n NMR-based metabolomics provides information regarding organ-specific toxicity, monitor the onset and progression of toxicological effects, and recognize biomarkers of toxicity. An upcoming challenge of metabolomics is to explain the cellular metabolome for purposes of understanding cellular functions. Such information is crucial if metabolomics is to supply a balancing dataset alongside genomics and proteomics are often wont to construct network models to explain cellular functions. NMR data are vastly reproducible and quantitative over a wide vigorous range and are unparalleled for determining structures of unknowns.

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\r\n Diverse analytical techniques are needed to achieve higher coverage of metabolites present within a biological system, which consists of a mass of molecules, having a variety of physical and chemical properties and existing as a dynamic home in biological samples. The application of mass spectrometry has increased exponentially since the discovery and innovation of electrospray ionization and matrix-assisted laser desorption ionization techniques.

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\r\n Metabolomics Analytical approaches for can be categorized largely into two discrete groups targeted or untargeted. These approaches can further be segmented as metabolic profiling, using an untargeted approach or metabolite identification and quantitation using a targeted approach. A diverse terminology for the definition of metabolic approaches has been used by various metabolomics research areas.

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\r\n Cancer biomarkers have many potential applications in cancer diagnosis, including screening, diagnosis, risk assessment, prediction of response to treatment, and monitoring of progression of the disease. Metabolomics is growing within the field with particular attention to its application as a biomarker in cancer diagnosis. Biomarkers could incorporate a good scope of biochemical elements, for instance, differing types of lipids, enzymes, proteins, macromolecules, and tiny metabolites, sugars, cytogenetic parameters and cytokinetic etc.

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\r\n Metabolomics is new omics platform that offers great potential for the diagnosis and prognosis of neurodegenerative diseases as an individual metabolome reflects alterations in genetic, transcript, and protein profiles and effects from the environment. Small numbers of metabolites have been used to diagnose complex metabolic diseases as well as monogenic disorders such as inborn errors of metabolism. Metabolic alterations in Cardiopulmonary Vascular Dysfunction are the leading purpose of death worldwide which is affecting the functions of the blood vessels and heart.

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\r\n Clinical metabolomics is achieving appreciation as an essential tool in precision medicine. Significant progress in separation science, mass spectrometry, and nuclear magnetic resonance spectroscopy occurring within the past few years are responsible for strengthening the analytical basis for metabolite identification and measurements in clinical samples. Metabolomics plan in the modern clinical approaches will allow a generous of diseases mechanisms and pathophysiological conditions, as well as providing innovative tools for novel diagnostic and prognostic approaches. Decades of research have energetically recommended that metabolism is not a self-regulating network operating independently.

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\r\n Nutritional metabolomics is using chemical profiling of tiny molecules to support the assimilation of nutrition and diet in complex bio-systems research. Nutrigenomics is a branch of nutritional genomics which deals with the effects of foods and food constituents on gene expression. Foodomics derived from the digestion and biotransformation of foods and their constituents during which MS techniques are considered indispensable.

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\r\n Genomics uses a combination of recombinant DNA, DNA sequencing methods, and bioinformatics, to assemble, and analyse the structure and function of genomes. Thus, proteins structure body structures, for instance, organs and tissues and additionally control concoction responses and convey motions between cells. Genomics likewise includes the sequencing and examination of genomes through employments of high throughput DNA sequencing and bioinformatics to gather and break down the capacity and structure of whole genomes.

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\r\n Cancer genomics is the study of the entirety of DNA sequence and gene expression differences between tumour cells and normal host cells. It aims to understand the genetic basis of tumour cells its proliferation and the evolution of the cancer genome under mutation and selection by immune system, the body environment and therapeutic interventions.

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\r\n Protein expression refers to the way in which proteins are synthesized, modified or changed and regulated in living beings or organisms. Recombinant protein expression refers to the construct of proteins which derived from recombinant DNA. In protein research, protein expression can apply to either the object of study or the laboratory techniques required to manufacture proteins. Protein analysis is the bioinformatics study of protein structure, it’s interaction and function using database searches, sequence comparisons, structural and functional predictions.

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\r\n In paediatric medicine, the potential applications for metabolomics a highly informative technique which will even be used on non-invasively collected samples. NMR- based Metabolomics might functions a promising approach for the diagnosis and prediction of mortality in septic shock during a paediatric population which quantitative metabolomics methods can be applied in the clinical evaluations of paediatric septic shock.

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\r\n Metabolic engineering is the need of genetic engineering to modify the metabolism of an organism which deals with measurement of metabolic fluxes and elucidation of their control as determinants of cell physiology and metabolic function. An innovative aspect of metabolic engineering is that it evacuate from the outdated reductionist paradigm of cellular metabolism, taking a holistic view. Metabolic engineering is acceptable as a framework for the analysis of genome wide differential organic phenomenon data, together with data on protein content and in-vivo metabolic fluxes. The main aim of metabolic engineering is to manipulate metabolite production.

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\r\n Lipidomics is an increasing field with plentiful applications. ESI mass spectroscopy is used to investigate the different cell types. Identification of lipid composition and quantification of cellular lipids gives us details about the lipid related pathway which also helps in identification of metabolic pathways and the effected enzymes. The need for bioinformatics is to maintain and integrate the experimental data in various aspects, such as-database design, visual display, for lipid classification analysis, and ontologies and play diverse roles in human physiology.

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