Metabolomics

Vladimir Tolstikov, Ph.D., is Director of Metabolomics at BERG. He received B.S. and M.S in Organic Chemistry in 1977 from M.V. Lomonosov Institute of Fine Chemical Technology, in Moscow, Russia. He received Ph.D. in Organic Chemistry in 1983 from the Institute of Chemical Means for Plant Protection, Moscow, Russia. He is a pioneer in HILIC separations development applied to Metabolomics. During his career he was working in leading research institutions in USA, Germany, Hungary and Russian Federation. He has joined Eli Lilly and Company in 2012. He is author contributor and participant of 45 conferences, 5 book chapters, and 54 articles.

Metabolomics, Mass Spectrometer, HPLC.

Scott Tebbutt is Associate Professor in the Department of Medicine, Division of Respiratory Medicine, University of British Columbia, and Principal Investigator at the James Hogg Research Centre, Institute for Heart + Lung Health, St. Paul’s Hospital, Vancouver, Canada. Since 2006, he has served as Co-Director of the Molecular Phenotyping and Genotyping Core of the James Hogg Research Centre, and he is currently Director of the Technology Development Core. He is also Chief Scientific Officer of the Prevention of Organ Failure (PROOF) Centre of Excellence, focused on heart, lung and kidney failure. Dr. Tebbutt earned his B.A. degree in Biochemistry from the University of Oxford (Oriel College), England in 1989, and his Ph.D. in Molecular Genetics from the University of East Anglia in 1993 (supervised by Dr. David Lonsdale, Cambridge Laboratory, John Innes Centre, England). He pursued post-doctoral fellowships in the laboratories of Professor Ann Harris (University of Oxford, Institute of Molecular Medicine) and Professor Diana Hill (University of Otago, Dunedin, New Zealand), where he studied the molecular genetics of cystic fibrosis. He was appointed Research Fellow at the University of Otago (1995-2001), leading a research team investigating the genomics of the sheep cystic fibrosis locus. He was seconded to a start-up biotechnology company (Global Technologies (NZ) Ltd.) as Director of Genomics (1999-2001). He moved to Canada in 2001, and was Senior Researcher in the Centre for Biomedical Research (University of Victoria, 2001-2002), prior to being recruited to the James Hogg Research Centre (formerly the iCAPTURE Centre) at St. Paul’s Hospital, Vancouver (2002).

Dr. Tebbutt’s research programme is focused on the genomics of complex respiratory disease, including the early and late reactions in allergic asthma and rhinitis. He also leads a multidisciplinary collaboration to investigate interactions between fungal spores and human airway cells. His research combines hypothesis-driven study of biological mechanisms with the development of advanced tools and technology (including bioinformatics and microfluidics-based systems) to better facilitate basic and translational research. Dr. Tebbutt has published original research contributions in journals such as the Proceedings of the National Academy of Sciences (U.S.A.), Journal of Medical Genetics, Genomics, BioTechniques, Bioinformatics, BMC Bioinformatics, BMC Medical Genomics and PLoS ONE. He has published numerous technical reviews as well as book chapters on the role of genetic variation in respiratory disease. He has served as reviewer on several grant panels, including the Canadian Institutes of Health Research and the Michael Smith Foundation for Health Research, and he is Associate Editor for the journal BMC Genetics. Dr. Tebbutt has received several fellowships and awards, including an Edward Penley Abraham Research Trust Fellowship (U.K.), a Journal of Cell Science Traveling Fellowship Award, and a Research Fellowship from the Cystic Fibrosis Association of New Zealand. He has been awarded competitive research funding from organizations such as the National Sanitarium Association (Canada), the British Columbia Lung Association, AllerGen NCE Inc. (Allergy, Genes and Environment Network), the Canadian Institutes of Health Research, the BC Proteomics Network, and the Wellcome Trust (U.K.).

Dr. Rui Wang has served Lakehead University since 2004, first as the Vice President of Researchand currently under the title of Vice President of Research, Economic Development and Innovation. Dr. Wang came to Lakehead from the University of Saskatchewan, where he was a Professor of Physiology and leader of both the Cardiovascular Research Group and the Cardiovascular and Respiratory Network. Prior to this, Dr. Wang was a Principal Investigator from 1995 to 2003 at the Mount Desert Island Biological Laboratory in Maine, USA, and an Assistant Professor at the Université de Montréal from 1993 to 1997. Dr. Wang was trained in China as a medical doctor, and later received his PhD degree in 1990 from the University of Alberta.

Gasotransmitters in cardiovascular system. Molecular basis and structure-function relationship of voltage-gated K (Kv) channels and ATP-sensitive (K ATP ) channels in vascular smooth muscle cells (SMCs) Health applications of novel nutraceutical and herb products

Viktor Kotolupov is heading both the Centre of homeostatic legal studies and company Kotolupov DOO, Vipava, Slovenia since 1991. The main directions of research are including but not limited to alternative medicine practice focused on transfer of practical results to biological, Pharmaceutical, Medical and legal knowledge. The main results are in description of general properties of living systems - consistent patterns and common laws in living systems, description of several diseases including cancer, various mental disorder diseases and psyche. Centre of homeostatic legal studies develops several new scientific directions in biology and medicine with emphasis on biological and sociological systems. Numerous scientific works are published in the international journals.

System biology and the principles of self-organization of all living systems, in such a way that human can work out new definitions of many incurable diseases on the basis of understanding their causes and mechanisms, and new ways of treating the patients both with the use of existing medication with minimal side effects as well as new drugs.

Hesham H. Ali is a Professor of Computer Science and the Lee and Wilma Seaman Distinguished Dean of the College of Information Science and Technology, at the University of Nebraska at Omaha (UNO). He currently serves as the director of the UNO Bioinformatics Core Facility. He has published numerous articles in various IT areas including scheduling, distributed systems, data analytics, wireless networks, and Bioinformatics. He has also published two books in scheduling and graph algorithms, and several book chapters in Bioinformatics. He is currently serving as the PI or Co-PI of several funded projects funded in the areas of data analytics, wireless networks and Bioinformatics. He has been leading a Research Group at UNO that focuses on developing innovative computational approaches to classify biological organisms and analyze big bioinformatics data.The research group is currently developing several next generation big data analytics tools for mining various types of large-scale biological and medical data. He has also been leading two projects for developing secure and energy-aware wireless infrastructure to address tracking and monitoring problems in medical environments, particularly to study mobility profiling for healthcare research.

Distributed systems, data analytics, wireless networks, and Bioinformatics.

Houkai Li has completed his PhD at the age of 32 years from Shanghai Jiao Tong University and Postdoctoral studies from University of North Carolina (2011.8-2013.5) and Chinese Academy Sciences (2008.11-2011.3) respectively. He is now a Professor at Center for Traditional Chinese Medicine and Systems Biology in Shanghai University of Traditional Chinese Medicine. He has published over 22 papers in reputed journals.

Alexander A. Kamnev is a Leading Scientist at the Institute of Biochemistry and Physiology of Plants and Microorganisms, Russian Academy of Sciences (Saratov, Russia). He graduated from Saratov State University with a MSc degree in chemistry (1980); received his Cand. Sci. (PhD equivalent; 1992) and DSc (2002) in physical chemistry from the same University. His scientific background included physical chemistry and electrochemistry of transition metal hydroxides. Since mid-90s, his research has been focused on the application of spectroscopic techniques in studying biomolecules, biocomplexes, supramolecular structures, microbial cells; physicochemical aspects of plant-microbe interactions, microbial metabolic responses to stresses and external agents; spectroscopic detection of biospecific interactions using biofunctionalized noble-metal plasmonic nanoparticles; bioanalytical applications of vibrational (FTIR, Raman) and Mössbauer (nuclear gamma-resonance) spectroscopies. Professor Kamnev has been the leader or coordinator of a number of international research projects supported by various grants. He is the main author of over a hundred papers in peer-refereed international journals and several invited review chapters in monographs. Professor Kamnev has been an invited/plenary lecturer and a member of Organizing Committees or Advisory Boards of a number of large international scientific meetings. He has been regularly involved in refereeing international research proposals and manuscripts for many high-rank scientific journals published by Elsevier, Springer, Wiley, American Chemical Society, etc., and is an Editorial/Advisory Board member of several international scientific journals.

Application of spectroscopic techniques in studying biomolecules, biocomplexes, supramolecular structures, microbial cells; physicochemical aspects of plant-microbe interactions, microbial metabolic responses to stresses and external agents; spectroscopic detection of biospecific interactions using biofunctionalized noble-metal plasmonic nanoparticles; bioanalytical applications of vibrational (FTIR, Raman) and Mössbauer (nuclear gamma-resonance) spectroscopies

Dr. Vladimir E. Bondarenko is an Associate Professor at Georgia State University, USA. He obtained his Ph.D. in Physical and Mathematical Sciences from Moscow State University (Russia) in 1990. Since that time, he worked at Radiotechnical Institute of the Russian Academy of Sciences, Institute of Biochemical Physics of the Russian Academy of Sciences, University of Buffalo, and Georgia State University. Dr. Bondarenko has published more than 50 research papers in the fields of cardiac cell models, neural networks, models of cardiac arrhythmias, ion channel models. He is a member of the American Heart Association, American Physiological Society, and Biophysical Society.

Dynamical systems, Neuronal and Cardiac cell models, Neural networks, Models of cardiac arrhythmias, Ion channel models.

Professor Li Zhang completed her PhD at UCLA and postdoctoral studies at the MIT department of Biology. She is the Cecil H. and Ida Green Distinguished Chair in Systems Biology Science at the University of Texas at Dallas. Professor Zhang’s laboratory has studied heme signaling and function for 20+ years and published many original research articles and a book entitled “Heme Biology: The Secret Life of Heme in Regulating Diverse Biological Processes” on this subject. Professor Zhang’s laboratory has also helped unravel the functions of molecular chaperones, oxygen signaling, and the actions of neurotoxicants. Professor Zhang’s recent research interest is to elucidate the metabolic and signaling network coordinating the functions of heme and mitochondria to promote lung tumorigenesis.

Dr. Li Zhang has made major contributions to understanding the molecular mechanisms underlying heme signaling in eukaryotic cells. Heme is central to oxygen sensing and utilization in virtually all living organisms. In mammals, heme is critical for erythroid, hepatic, and neuronal functions. Oxygen sensing is directly related to many fundamental physiological and pathological processes, including angiogenesis, tumor development, and ischemia. Investigating the molecular mechanism of oxygen sensing and heme signaling is the main objective of Dr. Zhang2s lab. Furthermore, Dr. Zhang's lab is interested in investigating the molecular mechanisms by which common neurotoxicants act in neural cells, because studies of neurotoxicants should facilitate the understanding of many neural functions and neurological diseases. Dr. Zhang2s lab combines approaches of molecular and cellular biology with genomics and computational approaches to elucidate the global molecular mechanisms underlying cellular responses to environmental stressors, including hypoxia and environmental toxicants.